Dry Powder Inhalation
Scalable Dry Powder Inhalation Services
Experic provides customized solutions for your dry powder inhalation (DPI) development and manufacturing needs. From drug product development and GMP manufacturing to clinical trial supply packaging and distribution, we offer advanced DPI capabilities backed by a quality-driven approach.
Customized Services for DPI Development & Manufacturing
Whether working with reservoir or single-dose devices, our comprehensive services ensure successful outcomes.
Dry Powder Inhalation:
Formulation Development
We tailor our formulation development to the specific characteristics of each powder compound, ensuring the best solution for lactose-based, spray-dried formulations, cohesive powders, and pure active pharmaceutical ingredients. Our process addresses key factors such as aerosolization of fine particles, clumping, and bridging properties. Our DPI formulation development capabilities include:
- Early DPI development for any single-dose unit
- Process development for dry powder inhalation
- Formulation development and optimization
- Clinical scale low-shear and high-shear blending services and equipment
Dry Powder Inhalation:
Formulation Manufacturing
Accurate dosing and filling of powders is a common challenge in drug product development,even for favorable formulations. At Experic, we address this formulation manufacturing challenge with state-of-the-art equipment, our team’s vast experience with powders, and innovative solutions designed to handle a wide variety of product characteristics, particle sizes, doses, and throughput requirements.
Our DPI formulation manufacturing capabilities include:
- Capsule filling for sizes ranging from 3 to 00
- Doses from 1 mg to 50 mg, with reservoir device filling up to 5 g
- Weight verification up to 100%
- Environmental controls maintaining less than 10% relative humidity
- Blister packaging
- Equipment includes:
- Harro Höfliger Drum Lab
- Modu-C LS IPK with drum
- Modu-C MS
- MicroVibe TT
- SDM auger
DPI Formulation and Aerosolization
We implement phase-specific formulation development processes for lactose-based and spray-dried compounds to optimize DPI performance. We account for aerosolization, clumping, and powder bridging characteristics during this process to ensure maximum powder efficacy. Learn more about our filling study observations.
Choose Experic’s Dry Powder Inhalation Services
- Over a decade of experience in DPI formulation and development
- Full suite of clinical and commercial manufacturing capabilities
- Expertise in handling cohesive powders, pure APIs, and complex formulations
- Advanced equipment for precision capsule filling and environmental controls
Inhalation: Connecting Formula to Filling
The chemical and physical properties of the powder determine whether a DPI product can be manufactured at scale.
In this webinar, DPI product formulation characteristics—including rheology, density, and cohesiveness—will be examined as sources of potential process risk. A case study will demonstrate the impact of drug product characteristics on processing.
Dry Powder Inhalation Modalities
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Single-dose unit development
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Lactose-based and spray-dried formulations
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Capsule sizes from 3 to 00
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Doses from 1 mg to 50 mg
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Reservoir devices up to 5 g
Specialist Services
Experic offers bespoke development, manufacturing, and clinical packaging, labeling, storage, and distribution services to meet your product's unique needs.